Blar i forfatter "Martinaityte, Ieva"
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Bone mineral density is associated with Vitamin D related rs6013897 and estrogen receptor polymorphism rs4870044: The Tromsø study
Martinaityte, Ieva; Jorde, Rolf; Emaus, Nina; Eggen, Anne Elise; Joakimsen, Ragnar Martin; Kamycheva, Elena (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-03-02)Background:<br>Bone mineral density (BMD) is determined by bone remodeling processes regulated by endocrine, autocrine and genetic mechanisms. Thus, some studies have reported that BMD is associated with single nucleotide polymorphisms (SNPs) associated with vitamin D receptor (VDR), serum 25(OH)D levels and estrogen receptor 1 (ESR1), but without consensus. Therefore, we aimed to map and compare ... -
Incidence of dementia over a period of 20 years in a Norwegian population
Johnsen, Bente; Martinaityte, Ieva; Wilsgaard, Tom; Schirmer, Henrik (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-09-29)INTRODUCTION: In Norway, the prevalence of dementia is higher than in demographically comparable, high income countries, but reliable incidence studies are lacking. This study calculated the incidence of age-specific dementia from 2000 to 2019.<p> <p>METHODS: Participants from The Tromsø Study (n = 44,214) were included. Participants with a dementia diagnosis (n = 2049 cases) were identified. ... -
Leisure Time Physical Activities’ Association With Cognition and Dementia: A 19 Years’ Life Course Study
Johnsen, Bente; Strand, Bjørn Heine; Martinaityte, Ieva; Lorem, Geir Fagerjord; Schirmer, Henrik (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-15)Introduction: Cognitive impairment is one of the main disabilities in dementia. Physical activity (PA) has been suggested as protective for dementia. However, the findings are disparate in studies, and the question of whether this is because of reverse causality is still open. We aimed to explore the association of PA with cognition in people who later developed dementia compared to those who ... -
Storage of vitamin D in adipose tissue and associations between vitamin D related genetic variants and diabetes, myocardial infarction, cancer, death, and low bone mineral density. Results from a high-dose vitamin D study and the Tromsø Study
Martinaityte, Ieva (Doctoral thesis; Doktorgradsavhandling, 2018-03-22)Cholecalciferol (vitamin D) is a biologically active substance, which acts in both skeletal and non-skeletal metabolic pathways, and is stored most in adipose tissue. Its active metabolite 1,25-dihydroxyvitamin D (1,25(OH)2D), bound to the vitamin D receptor (VDR), regulates gene expression and initiates rapid responses in the cells that regulate bone and adipose tissue homeostasis, lead to ...